The pineal gland is a small endocrine gland in the brain that has always fascinated me. This is the part of the body that produces melatonin, a hormone that regulates sleep-wake cycles and circadian rhythms. . The production and secretion of melatonin by the pineal gland are tightly controlled by exposure to daylight (day/night cycles). During the day, light signals from the retina are transmitted to a very important part of the brain called the hypothalamus, which communicates with the pineal gland suppressing melatonin production. At night, when the retina no longer detects light, the hypothalamus signals the pineal gland to release melatonin into the bloodstream, inducing sleep. This is why having a job that requires you to work at night, or traveling to a different time zone (jetlag) will alter your circadian rhythms. . In many animals, this same process also helps regulate seasonal behaviors like mating or hibernation (the duration of daylight signals the body about seasonal changes). . The natural production of melatonin decreases with age, this is why older people tend to sleep less than younger people. The peak of melatonin production in life is childhood and adolescence. Now you know why teenagers sleep so much! . By the way, over time the pineal gland often develops something called brain sand (corpora arenacea), which are calcified deposits primarily made of calcium phosphate and carbonate. These calcifications are common in older people, but they seem to be harmless. However, some scientists have hypothesized that excessive accumulation of brain sand in the pineal gland could contribute to certain sleep problems. . For this video I used a Leica ZOOM 200 stereoscope and an Olympus BX41 microscope at up to 1000x magnification
#microscopy #microscope #histology #pinealgland #melatonin #circadianrythm #sleep #drbioforever