Children with non-IgE-mediated CMPA tend to develop tolerance at an earlier age and at a higher percentage compared to those with IgE-mediated disease. In subjects with severe symptoms CMPA may persist for longer or ever. Most of the current guidelines on the diagnosis and management of CMPA suggest reevaluation of milk-allergic children every 6-12 months, and reintroduction of CM after a negative Oral Food Challenge (OFC). The duration of an allergy to cow’s milk protein varies, but most children will have outgrown the allergy by the age of 2-3 years (Fiocchi, 2010; Host et al., 2014; Kneepkens et al., 2009; Skripak et al., 2007). Still, in some cases, CMPA can persist into adolescence (Skripak et al., 2007). According to a position paper by ESPGHAN (2024), CMPA also exists in exclusively breastfed infants. However, it is uncommon and suffers from over-diagnosis. CMPA is also over-diagnosed in formula and mixed fed infants. Over-diagnosis of CMPA occurs much more frequently than under-diagnosis; both could have harmful consequences. If your child has a CMPA, working with a dietitian to ensure nutritional needs are being met on a limited diet may be helpful. Save and share if this was helpful.
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